Dr. Sang-Hyuk Lee in the Department of Physics & Astronomy and Institute for Quantitative Biomedicine (IQB) at Rutgers University is seeking applications for postdoctoral positions from highly skilled and motivated individuals with expertise in one or more of the following areas: single-molecule biophysics, optics, and instrumentation and control engineering.
Lee lab (http://sanghyuklee.rutgers.edu) is specialized in single-molecule methods, optical tweezers and super-resolution fluorescence microscopy in particular, to study various intriguing biological processes through interdisciplinary collaborations. The lab has recently developed one-of-a-kind microscope platform (https://www.osapublishing.org/oe/abstract.cfm?uri=oe-26-7-8049). The candidate is expected to conduct research on further advancing the instrument through integration of optical-tweezers-based force spectroscopy, single-particle tracking, surfaced-enhanced Raman spectroscopy, and super-resolution localization microscopy (PALM/STORM) towards a multimodal single-molecule method that is applicable in vivo. The candidate is also expected to work on one or more of the following biology projects in close collaboration with researchers at Rutgers and other institutes: (1) DOE-sponsored project on multimodal in vivo single-molecule imaging of plant cell wall synthesis; (2) NSF-sponsored project on mechano-transduction in neurons with molecular tension probes and super-resolution imaging; (3) Innate immunity research with single-molecule methods; and (4) Single-molecule study of DNA replisome. This is 1-year appointment with the possibility of reappointment for up to 2 additional years. The start date is flexible, but preference will be given to candidates who can begin in late 2018.
Minimum Education and Experience:
Applicants must have a PhD in biophysics, physics, chemistry, chemical engineering, biology, bioengineering, electrical engineering or related disciplines. Research experience in at least one of the followings is preferred: single-molecule microscopy (optical tweezers, smFRET), optical instrument design and construction, advanced optical microscopy, nonlinear optics, instrumentation and control, Raman spectroscopy, microfluidics, plasmonics, and soft matter physics. Physicists or engineers with strong background in optics or instrumentation design/control who would like to apply their expertise to important biological problems are highly encouraged to apply.
Required Knowledge, Skills, and Abilities:
Proficiency in high-level programming language (e.g., Mathlab, Python, IDL) is essential. One or more of the following technical expertise are strongly preferred: deep working knowledge and experience in measurement and control with modern instrument using LabView; optical instrumentation; and single-molecule assay development. Experience with cloning, protein expression/purification/characterization, and cell culture and imaging are desirable but not required. The candidates are expected to be capable of conducting not only independent research but also collaborative works in interdisciplinary teamwork environment. Proficiency in both written and oral communication skills in English is required for manuscripts/grants preparation, public presentation, and collaboration with other lab members.
The candidate will be provided with research opportunity to utilize and develop a unique home-built multifunctional single-molecule/super-resolution/holographic optical tweezers/Raman microscope. In addition, state-of-the-art equipment, such as cryo-EM, NMR, and mass spectrometry, is readily available by way of in-house core facilities of IQB in which Lee lab is located. IQB is also the world headquarter of the Research Collaboratory for Structural Bioinformatics (RCSB) consortium and the Protein Data Bank (PDB), providing distinctively creative and vibrant interdisciplinary research environment together with neighboring institutes such as Physics, Center for Advanced Biotechnology and Medicine (CABM), Robert Wood Johnson Medical School, and Waksman Institute.
Posting Number: 18FA0616
Location: Busch (RU-New Brunswick)
Internal Number: 76974
About Rutgers University
Rutgers, The State University of New Jersey, is a leading national public research university and the state's preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities. As it was at our founding in 1766, the heart of our mission is preparing students to become productive members of society and good citizens of the world. Rutgers teaches across the full educational spectrum: preschool to precollege; undergraduate to graduate and postdoctoral; and continuing education for professional and personal advancement. Rutgers is New Jersey's land-grant institution and one of the nation's foremost research universities, and as such, we educate, make discoveries, serve as an engine of economic growth, and generate ideas for improving people's lives.